Name             :  LUBNA YASMIN  
                                           
         Profession      :   Medical docotor, work in Sweden

                                    MD (2009-2015), Cell biologist, PhD in Pathology (2004-2007) Umeå university, BSc and MSc in Biochemistry (1991-95) Dhaka University)

         
         Born: 1974

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           PUBLICATIONS:

• Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 protein. Lubna Yasmin*1,2, Jeffrey L. Veesenmeyer†1, Maureen H. diaz†3, Matthew S. Francis*‡, Christian Ottmann§, Ruth H. Palmer*, Alan R. Hauser† and Bengt Hallberg*4. Biochem. J. (2010) 427. Learn more

• Exoenzyme S of Pseudomonas aeruginosa: cellular targets and interaction with 14-3-3. Yasmin Lubna; PhD thesis 2007; New Series No. 1125; ISSN:0346-6612; ISBN:978-91-7264-414-4; Umeå University library publication. Learn more.

• Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis. EMBO J. 2007 Feb 7;26(3):902-13. Epub 2007 Jan 18. OttmannC, Yasmin L, Weyand M, Veesenmeyer JL, Diaz MH, Palmer RH, FrancisMS, Hauser AR Wittinghofer A, Hallberg B. Learn more.

• Delineation of exoenzyme S residues that mediate the interaction with 14-3-3 and its biological activity. FEBS J. 2006 Feb;273(3):638-46. Yasmin L, Jansson AL, Panahandeh T, Palmer RH, Francis MS, Hallberg B. Learn more. Learn more.

• Exoenzyme S of Pseudomonas aeruginosa is not able to induce apoptosis when cells express activated proteins, such as Ras or protein kinase B/Akt. Lubna Yasmin ,Anna L. Jansson, Patricia Warne, Julian Downward, Ruth H. Palmer and Bengt Hallberg. Cell Microbiol. 2006 May;8(5):815-22. Learn more.

• Mitochondrial ribosomes in a trypanosome. Tittawella I, Yasmin L, Baranov V;Biochem Biophys Res Commun; 2003 Aug 1; 307(3):578-83. Learn more.

• Treatment failure with the use of ciprofloxacin for gonorrhoea correlates with the prevalence of fluoroquinolone-resistant Neisseria gonorrhoeae strains in Bangladesh. Rahman M, Alam A, Nessa K, Nahar S, Dutta DK, Yasmin L, Monira S, Sultan Z, Khan SA, Albert MJ. Clin Infect Dis 2001 Mar 15; 32 (6): 884-9. Learn more.

• Molecular typing of Nesseria gonorrhoeae isolated from commercial sex workers (CSWs) in Dhaka City. Yasmin Lubna. MSc. Thesis 1995; Dept. Of Biochemistry, Univ of Dhaka. Learn more.

 
                  ABSTRACTS:

• Molecular mechanism of exotoxin A action in human ovarian cancer cell. Yasmin L and Lundin E. Keystone symposia publication: Target cancer theraputics (X7/X8) meeting Mar 27-April 1, 2009, p-150.

• Mechanisms of cell death induced by ExotoxinA in ovarian cancer. Nina Johansson, LubnaYasmin and Eva Lundin. Master’s thesis publication in Biomedicine; Jan 2009; Umeå University.

• An interaction between 14-3-3 and ExoS of P.aeruginosa is necessary for ExoS cytotoxicity and enzymatic activity. Yasmin L, Francis MS, Hallberg B. Journal of Cystic Fibrosis; Vol 5: 2006; S18; 77.

• An interaction between 14-3-3 and ExoS of P.aeruginosa is necessary for ExoS cytotoxicity and enzymatic activity. Yasmin L, Francis MS, Hallberg B. The 2nd National Meeting in Infectious Biology; Oct 2006; 5; P-31.

 
            MANUSCRIPT:
 

           1.  Apoptotic signalling induction by exotoxin A related to expression of Cyclin D1, Cyclin E, c-Myc and P27kip1 in ovarian cancer cell. Yasmin L, Johansson N, Liu K and Lundin E. Manuscript 2009. 

               
          Short description of research interest:
 

I have been achieved research experiences in receptor signalling and research using cell culture system is my basic experience. In order to contribute towards the success of my potential, I desire to obtain a post doctoral experience in biomedical research and Image analysis which further can complement my research career. Besides research, I want to work in clinical practices.  
 

Since December 2007, I have started a pioneering research to investigate molecular mechanisms of exotoxin A action in human ovarian cancer. Bacterial products such as Exotoxin A have been used in an effort to reduce the growth rate of tumors as because it can be able to trigger apoptosis. However, the mechanism by which ETA induce apoptosis has not yet emerged. In this project, I aim to investigate cytotoxic effects at cellular level using different ovarian cell lines and to reveal the cell signal transduction pathway involved behind exotoxin A induced apoptosis. Further in continuation, I am analyzing PRL signalling pathway in ovarian cancer cell line as because I found that PRL signaling can induce the expression of c-Myc in the cell line treated with exotoxin A.
 

In November 2007, I defended my thesis entitled ‘’Exoenzyme of Pseudomonas aeruginosa: cellular target s and interaction with 14-3-3’’. My research interest was to analyze how ExoS induce cytotoxicity in host using structural and biochemical observation on survival and death signal transduction pathways e g RAS signalling, AKT signalling and apoptosis signalling. Cell lines were used in order to understand the functional and mechanical activation of ExoS-ADP- ribosyltransferase activity and cytotoxicity at the cellular level and to reveal critical residues of ExoS responsible for cell cytotoxicity and to elucidate the critical signalling targets of ExoS by which it mediates cell death. The research was performed in national as well as international collaborations and studies also extended to the pathogenesis experiment in mouse model and structural analysis of ExoS/14-3-3 molecules. The structural analysis of ExoS/14-3-3 molecules provide information to develop therapeutic against Pseudomonas aeruginosa infection and this study was performed with collaboration in Dortmund Germany. Further, the ExoS induced pathogenesis study was investigated in more relevant clinical model such as in a mouse with acute pneumonia model, performed with collaboration in Northwestern University, Chicago, USA which provide supportive evidences for the cytotoxicity analysis at cellular level and structural analysis.